SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression

• Main Authors: Yang Q. Xia (Author), Ren J. Hua (Author), Chen Juan (Author), Zhou H. Zhong (Author), Cheng S. Tao (Author), Ren Fang (Author), He Lin (Author), Gong Rui (Author), Chen Yong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug resistance (MDR) due to overexpression of MDR1 is a major obstacle that hinders the treatment of hepatocellular carcinoma (HCC). In this study, we explored the function and underlying molecular mechanism of SIRT6 in MDR of HCC. Chemotherapeutic agents (doxorubicin, cisplatin, and sorafenib...