SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression
Multidrug resistance (MDR) due to overexpression of MDR1 is a major obstacle that hinders the treatment of hepatocellular carcinoma (HCC). In this study, we explored the function and underlying molecular mechanism of SIRT6 in MDR of HCC. Chemotherapeutic agents (doxorubicin, cisplatin, and sorafenib...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2018-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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