A NIR fluorescent probe for Vanin-1 and its applications in imaging, kidney injury diagnosis, and the development of inhibitor

• Ngā kaituhi matua: Zhenhao Tian (Author), Fei Yan (Author), Xiangge Tian (Author), Lei Feng (Author), Jingnan Cui (Author), Sa Deng (Author), Baojing Zhang (Author), Tian Xie (Author), Shanshan Huang (Author), Xiaochi Ma (Author)
• Hōputu: Pukapuka
• I whakaputaina: Elsevier, 2022-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Vanin-1 is an amidohydrolase that catalyses the conversion of pantetheine into the amino-thiol cysteamine and pantothenic acid (coenzyme A precursor), which plays a vital role in multiple physiological and pathological processes. In this study, an enzyme-activated near-infrared (NIR) fluorescent pro...