Design, Synthesis, and Biological Evaluation of Sulfonamide Methoxypyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors

Phosphatidylinositol 3-kinase (PI3K) plays an important role in cell proliferation, survival, migration, and metabolism, and has become an effective target for cancer treatment. Meanwhile, inhibiting both PI3K and mammalian rapamycin receptor (mTOR) can simultaneously improve the efficiency of anti-...

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Main Authors: Haotian Gao (Author), Zaolin Li (Author), Kai Wang (Author), Yuhan Zhang (Author), Tong Wang (Author), Fang Wang (Author), Youjun Xu (Author)
Format: Book
Published: MDPI AG, 2023-03-01T00:00:00Z.
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