The new H2S-releasing compound ACS94 exerts protective effects through the modulation of thiol homoeostasis

• Main Authors: Daniela Giustarini (Author), Valerio Tazzari (Author), Ivan Bassanini (Author), Ranieri Rossi (Author), Anna Sparatore (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The synthesis of a new dithiolethione-cysteine ethyl ester hybrid, ACS94, its metabolites, and its effect on GSH levels in rat tissues and on the concentration of circulating H2S is described. ACS94 rapidly enters the cells, where it is metabolised to cysteine and the dithiolethione moiety ACS48. Ex...