Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model

• Main Authors: Catarina Raposo (Author), Ana Karolina de Santana Nunes (Author), Rayana Leal de Almeida Luna (Author), Shyrlene Meiry da Rocha Araújo (Author), Maria Alice da Cruz-Höfling (Author), Christina Alves Peixoto (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We recently demonstrated that sildenafil reduces the expression of cytokines, COX-2, and GFAP in a demyelinating model induced in wild-type (WT) mice. Herein, the understandings of the neuroprotective effect of sildenafil and the mediation of iNOS/NO system on inflammatory demyelination induced by c...