pH Sensitive Erythrocyte-Derived Membrane for Acute Systemic Retention and Increased Infectivity of Coated Oncolytic Vaccinia Virus

• Main Authors: Kaelan T. Samoranos (Author), Alexandra L. Krisiewicz (Author), Bianca C. Karpinecz (Author), Philip A. Glover (Author), Trevor V. Gale (Author), Carla Chehadeh (Author), Sheikh Ashshan (Author), Richard Koya (Author), Eddie Y. Chung (Author), Han L. Lim (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oncolytic viruses have emerged as a promising modality in cancer treatment given their high synergy with highly efficient immune checkpoint inhibitors. However, their potency is limited by their rapid in vivo clearance. To overcome this, we coated oncolytic vaccinia viruses (oVV) with erythrocyte-de...