Prolonged Infusion of β-Lactams Decreases Mortality in Patients with Septic Shock: A Retrospective before-and-after Study

• Main Authors: Daniel Christoph Richter (Author), Maximilian Dietrich (Author), Lazar Detelinov Lalev (Author), Felix C. F. Schmitt (Author), Mascha Onida Fiedler (Author), Thomas Bruckner (Author), Dominic Stoerzinger (Author), Ute Chiriac (Author), Sabrina Klein (Author), Thilo Hackert (Author), Thorsten Brenner (Author), Alexander Brinkmann (Author), Markus A. Weigand (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Septic shock substantially alters the pharmacokinetic properties of β-lactams with a subsequently high risk of insufficiently low serum concentrations and treatment failure. Considering their pharmacokinetic (PK)/pharmacodynamic (PD) index, prolonged infusions (PI) of β-lactams extend the time that...