Pharmacological inhibition of protein tyrosine kinases axl and fyn reduces TNF-α-induced endothelial inflammatory activation in vitro

• Main Authors: Sophie F. Ellermann (Author), Rianne M. Jongman (Author), Matthijs Luxen (Author), Timara Kuiper (Author), Josee Plantinga (Author), Jill Moser (Author), Thomas W. L. Scheeren (Author), Gregor Theilmeier (Author), Grietje Molema (Author), Matijs Van Meurs (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Major surgery induces systemic inflammation leading to pro-inflammatory activation of endothelial cells. Endothelial inflammation is one of the drivers of postoperative organ damage, including acute kidney injury Tumour Necrosis Factor alpha (TNF-α) is an important component of surgery-induced pro-i...