Development of quantification methods of a new selective carbonic anhydrase II inhibitor in plasma and blood and study of the pharmacokinetics of its ophthalmic suspension in rats

• Autori principali: Alexander L. Khokhlov (Autore), Ilya I. Yaichkov (Autore), Mikhail K. Korsakov (Autore), Anton A. Shetnev (Autore), Nikita N. Volkhin (Autore), Sergey S. Petukhov (Autore)
• Natura: Libro
• Pubblicazione: Belgorod National Research University, 2023-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Introduction: Development of new bioanalytical methods is required for studying the systemic exposure of new selective inhibitor of carbonic anhydrase II, 4-(2-methyl-1,3-oxazole-5-yl)-benzenesulfonamide, and its N-hydroxymetabolite in plasma and in whole blood. The results of the experiment with a...