Phenyl-substituted aminomethylene-bisphosphonates inhibit human P5C reductase and show antiproliferative activity against proline-hyperproducing tumour cells

• 主要な著者: Giuseppe Forlani (著者), Giuseppe Sabbioni (著者), Daniele Ragno (著者), Davide Petrollino (著者), Monica Borgatti (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalysing the second and last step in proline synthesis, δ1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated. This leads to a higher proline content that exacerbates the effects o...