Carbon Ion Induces Cell Death and G2/M Arrest Through pRb/E2F1Chk2/Cdc2 Signaling Pathway in X-ray Resistant B16F10 Melanoma Cells

• Main Authors: Sha Li (Author), Hefa Huang (Author), Mengjie Xing (Author), Jin Qin (Author), Hong Zhang (Author), Yang Liu (Author), Liping Zhang (Author), Chao Zhang (Author), Zhongze Tian (Author), Xingxin Gao (Author), Rui Zhao (Author), Aihong Mao (Author)
• Format: Book
• Published: SAGE Publishing, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To explore the effect of high-LET carbon ion (C-ion) radiation on malignant melanoma, we systematically compared the radiobiological effects of C-ion with that of X-rays in B16F10 melanoma cells. Results showed that C-ion radiation statistically inhibited clonogenic survival capacity of B16F10 melan...