New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy

• Main Authors: Giulio Poli (Author), Miriana Di Stefano (Author), Joan Arias Estevez (Author), Filippo Minutolo (Author), Carlotta Granchi (Author), Antonio Giordano (Author), Salvatore Parisi (Author), Matteo Mauceri (Author), Vincenzo Canzonieri (Author), Marco Macchia (Author), Isabella Caligiuri (Author), Tiziano Tuccinardi (Author), Flavio Rizzolio (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PIN1 is considered as a therapeutic target for a wide variety of tumours. However, most of known inhibitors are devoid of cellular activity despite their good enzyme inhibitory profile. Hence, the lack of effective compounds for the clinic makes the identification of novel PIN1 inhibitors a hot topi...