Pathway-targeted pharmacogenomics of CYP1A2 in human liver

• Main Authors: Kathrin eKlein (Author), Stefan eWinter (Author), Miia eTurpeinen (Author), Matthias eSchwab (Author), Ulrich M Zanger (Author)
• Format: Book
• Published: Frontiers Media S.A., 2010-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human drug metabolizing cytochrome P450 (CYP) 1A2, is one of the major P450 isoforms contributing by about 5-20% to the hepatic P450 pool and catalyzing oxidative biotransformation of up to 10% of clinically relevant drugs including clozapine and caffeine. CYP1A2 activity is interindividually hi...