Bicyclol Alleviates Signs of BDL-Induced Cholestasis by Regulating Bile Acids and Autophagy-Mediated HMGB1/p62/Nrf2 Pathway

• Main Authors: Jingwen Zhao (Author), Maojuan Ran (Author), Ting Yang (Author), Liwei Chen (Author), Peixu Ji (Author), Xiuxiu Xu (Author), Lu Zhang (Author), Siyuan Sun (Author), Xin Liu (Author), Simin Zhou (Author), Lu Zhou (Author), Jie Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cholestasis is a liver disease characterized by the accumulation of toxic bile salts, bilirubin, and cholesterol, resulting in hepatocellular damage. Recent findings have revealed several key steps of cholestasis liver injury including the toxicity of bile acids and accumulation of proinflammatory m...