Cryptotanshinone Protects Cartilage against Developing Osteoarthritis through the miR-106a-5p/GLIS3 Axis

• Main Authors: Quanbo Ji (Author), Dengbin Qi (Author), Xiaojie Xu (Author), Yameng Xu (Author), Stuart B. Goodman (Author), Lei Kang (Author), Qi Song (Author), Zhongyi Fan (Author), William J. Maloney (Author), Yan Wang (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cryptotanshinone (CTS) has emerged as an anti-inflammatory agent in osteoarthritis (OA). However, the molecular mechanism underlying its potent therapeutic effect on OA remains largely unknown. MicroRNAs (miRNAs) act as crucial regulators in maintaining cartilage homeostasis. To investigate whether...