Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction

Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction

Two series of chalcone/aryl carboximidamide hybrids 4a-f and 6a-f were synthesised and evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives were further checked for their in vivo anti-inflammatory activity utilising carrageenan-induced rat paw oedema model. Comp...

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Main Authors: Tarek S. Ibrahim (Author), Amr H. Moustafa (Author), Ahmad J. Almalki (Author), Rasha M. Allam (Author), Abdulhamid Althagafi (Author), Shadab Md (Author), Mamdouh F. A. Mohamed (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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