Altered IL-7 signaling in CD4+ T cells from patients with visceral leishmaniasis.

• Main Authors: Shashi Kumar (Author), Shashi Bhushan Chauhan (Author), Shreya Upadhyay (Author), Siddharth Sankar Singh (Author), Vimal Verma (Author), Rajiv Kumar (Author), Christian Engwerda (Author), Susanne Nylén (Author), Shyam Sundar (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>CD4+ T cells play a central role in control of L. donovani infection, through IFN-γ production required for activation of macrophages and killing of intracellular parasites. Impaired control of parasites can in part be explained by hampered CD4+ T cells effector functi...