A Mechanistic Systems Pharmacology Model for Prediction of LDL Cholesterol Lowering by PCSK9 Antagonism in Human Dyslipidemic Populations

• Main Authors: K Gadkar (Author), N Budha (Author), A Baruch (Author), J D Davis (Author), P Fielder (Author), S Ramanujan (Author)
• Format: Book
• Published: Wiley, 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PCSK9 is a promising target for the treatment of hyperlipidemia and cardiovascular disease. A Quantitative Systems Pharmacology model of the mechanisms of action of statin and anti‐PCSK9 therapies was developed to predict low density lipoprotein (LDL) changes in response to anti‐PCSK9 mAb for differ...