Discovery of novel immunotherapeutic drug candidates for sciatic nerve injury using bioinformatic analysis and experimental verification

• Main Authors: Shengyou Li (Author), Beibei Yu (Author), Xue Gao (Author), Yi Zheng (Author), Teng Ma (Author), Yiming Hao (Author), Haining Wu (Author), Bin Wei (Author), Yitao Wei (Author), Zhuojing Luo (Author), Bing Xia (Author), Jinghui Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation following nerve injury and surgery often causes peripheral nerve adhesion (PNA) to the surrounding tissue. Numerous investigations independently examined the prevention or inhibition of PNA, however, an intervention targeting macrophages has not been fully elucidated. Basement membrane...