Indoline-5-Sulfonamides: A Role of the Core in Inhibition of Cancer-Related Carbonic Anhydrases, Antiproliferative Activity and Circumventing of Multidrug Resistance

• Main Authors: Stepan K. Krymov (Author), Alexander M. Scherbakov (Author), Lyubov G. Dezhenkova (Author), Diana I. Salnikova (Author), Svetlana E. Solov'eva (Author), Danila V. Sorokin (Author), Daniela Vullo (Author), Viviana De Luca (Author), Clemente Capasso (Author), Claudiu T. Supuran (Author), Andrey E. Shchekotikhin (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The overexpression and activity of carbonic anhydrase (CA, EC 4.2.1.1) isoforms CA IX and CA XII promote the accumulation of exceeding protons and acidosis in the extracellular tumor environment. Sulfonamides are effective inhibitors of most families of CAs. In this study, using scaffold-hopping, in...