Indoline-5-Sulfonamides: A Role of the Core in Inhibition of Cancer-Related Carbonic Anhydrases, Antiproliferative Activity and Circumventing of Multidrug Resistance

• Главные авторы: Stepan K. Krymov (Автор), Alexander M. Scherbakov (Автор), Lyubov G. Dezhenkova (Автор), Diana I. Salnikova (Автор), Svetlana E. Solov'eva (Автор), Danila V. Sorokin (Автор), Daniela Vullo (Автор), Viviana De Luca (Автор), Clemente Capasso (Автор), Claudiu T. Supuran (Автор), Andrey E. Shchekotikhin (Автор)
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• Опубликовано: MDPI AG, 2022-11-01T00:00:00Z.
• Предметы: article
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The overexpression and activity of carbonic anhydrase (CA, EC 4.2.1.1) isoforms CA IX and CA XII promote the accumulation of exceeding protons and acidosis in the extracellular tumor environment. Sulfonamides are effective inhibitors of most families of CAs. In this study, using scaffold-hopping, in...