Inducible expression of human C9ORF72 36× G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

Inducible expression of human C9ORF72 36× G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice

The hexanucleotide G4C2 repeat expansion in the first intron of the C9ORF72 gene accounts for the majority of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) cases. Numerous studies have indicated the toxicity of dipeptide repeats (DPRs), which are produced via repeat-associate...

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Main Authors: Fréderike W. Riemslagh (Author), Esmay C. van der Toorn (Author), Rob F. M. Verhagen (Author), Alex Maas (Author), Laurens W. J. Bosman (Author), Renate K. Hukema (Author), Rob Willemsen (Author)
Format: Book
Published: The Company of Biologists, 2021-02-01T00:00:00Z.
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3rd Floor Main Library

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