The effect of genetic variants in the transcription factor TSPYL family on the CYP3A4 mediated cyclosporine metabolism in kidney transplant patients

• Main Authors: Qinglian Zhai (Author), Dirk Jan A. R. Moes (Author), Teun vanGelder (Author), Maaike van derLee (Author), Jan‐Stephan Sanders (Author), Frederike J. Bemelman (Author), Johan W. deFijter (Author), Kathrin Klein (Author), Matthias Schwab (Author), Jesse J. Swen (Author)
• Format: Book
• Published: Wiley, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract CYP3A4 activity shows considerable interindividual variability. Although studies indicate 60%-80% is heritable, common single nucleotide variants (SNVs) in CYP3A4 together only explain ~10%. Transcriptional factors, such as the testis‐specific Y‐encoded‐like proteins (TSPYLs) family, have b...