Equilibrium solubility measurement of ionizable drugs - consensus recommendations for improving data quality

• Main Authors: Alex Avdeef (Author), Elisabet Fuguet (Author), Antonio Llinàs (Author), Clara Ràfols (Author), Elisabeth Bosch (Author), Gergely Völgyi (Author), Tatjana Verbić (Author), Elena Boldyreva (Author), Krisztina Takács-Novák (Author)
• Format: Book
• Published: International Association of Physical Chemists (IAPC), 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This commentary addresses data quality in equilibrium solubility measurement in aqueous solution. Broadly discussed is the "gold standard" shake-flask (SF) method used to measure equilibrium solubility of ionizable drug-like molecules as a function of pH. Many factors affecting the quality...