Equilibrium solubility measurement of ionizable drugs - consensus recommendations for improving data quality

• প্রধান লেখক: Alex Avdeef (লেখক), Elisabet Fuguet (লেখক), Antonio Llinàs (লেখক), Clara Ràfols (লেখক), Elisabeth Bosch (লেখক), Gergely Völgyi (লেখক), Tatjana Verbić (লেখক), Elena Boldyreva (লেখক), Krisztina Takács-Novák (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: International Association of Physical Chemists (IAPC), 2016-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

This commentary addresses data quality in equilibrium solubility measurement in aqueous solution. Broadly discussed is the "gold standard" shake-flask (SF) method used to measure equilibrium solubility of ionizable drug-like molecules as a function of pH. Many factors affecting the quality...