Equilibrium solubility measurement of ionizable drugs - consensus recommendations for improving data quality

• Автори: Alex Avdeef (Автор), Elisabet Fuguet (Автор), Antonio Llinàs (Автор), Clara Ràfols (Автор), Elisabeth Bosch (Автор), Gergely Völgyi (Автор), Tatjana Verbić (Автор), Elena Boldyreva (Автор), Krisztina Takács-Novák (Автор)
• Формат: Книга
• Опубліковано: International Association of Physical Chemists (IAPC), 2016-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

This commentary addresses data quality in equilibrium solubility measurement in aqueous solution. Broadly discussed is the "gold standard" shake-flask (SF) method used to measure equilibrium solubility of ionizable drug-like molecules as a function of pH. Many factors affecting the quality...