Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins

• Main Authors: Luna Prieto Garcia (Author), Anna Vildhede (Author), Pär Nordell (Author), Christine Ahlström (Author), Ahmed B. Montaser (Author), Tetsuya Terasaki (Author), Hans Lennernäs (Author), Erik Sjögren (Author)
• Format: Book
• Published: Wiley, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Statins are used to reduce liver cholesterol levels but also carry a dose‐related risk of skeletal muscle toxicity. Concentrations of statins in plasma are often used to assess efficacy and safety, but because statins are substrates of membrane transporters that are present in diverse tissu...