The case of dynamic intestinal obstruction, caused by an individual intolerance to vincristine in a child of 5 years

• Main Authors: S. S Postnikov (Author), V. A. Strykov (Author), M. N. Kostyleva (Author), E. S. Ilina (Author), A. N. Gracianskaya (Author), A. B. Strock (Author)
• Format: Book
• Published: Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products», 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the key enzymes involved in the first phase of biotransformation of drugs is cytochrome P450 (CYP450), represented predominantly in the liver. Vincristine is metabolized mainly by CYP3A5 (75 %) and to a lesser extent CYP3A4 (whose level is lower in children). Low expression (CYP3A5*3 genotype...