Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

• Main Authors: Yuxin Hao (Author), Jiabin Yan (Author), Courtney Fraser (Author), Aiping Jiang (Author), Murali Anuganti (Author), Roushu Zhang (Author), Kenneth Lloyd (Author), Joseph Jardine (Author), Jessica Coppola (Author), Rob Meijers (Author), Jing Li (Author), Timothy A. Springer (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Integrins are cell surface receptors that mediate the interactions of cells with their surroundings and play essential roles in cell adhesion, migration, and homeostasis. Eight of the 24 integrins bind to the tripeptide Arg-Gly-Asp (RGD) motif in their extracellular ligands, comprising the RGD-bindi...