Comparison of in-silico and in-vitro studies of benzimidazoleoxothiazolidine derivatives as m. Tubcerculosis transcriptor inhibitors

• Main Authors: Sonal dubey (Author), Sakshi Bhardwaj (Author), Prabitha Prabhakaran (Author), Subhankar Parboth Mandal (Author), Ekta Singh (Author)
• Format: Book
• Published: German Journal of Pharmaceuticals and Biomaterials, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel N-(4-alkyl-4-oxo-1,3-thiazolidin-3-yl)-2-(5-nitro-1H-benzimidazole-1-yl)acetamide derivatives were evaluated as M. tuberculosis transcription inhibitors using protein 3Q3S, by performing molecular docking and molecular dynamics studies. Twelve promising candidates exhibiting good binding inter...