Astrocyte-derived lactoferrin inhibits neuronal ferroptosis by reducing iron content and GPX4 degradation in APP/PS1 transgenic mice

• Main Authors: Yong-Gang Fan (Author), Ri-Le Ge (Author), Hang Ren (Author), Rong-Jun Jia (Author), Ting-Yao Wu (Author), Xian-Fang Lei (Author), Zheng Wu (Author), Xiao-Bei Zhou (Author), Zhan-You Wang (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Increased astrocytic lactoferrin (Lf) expression was observed in the brains of elderly individuals and Alzheimer's disease (AD) patients. Our previous study revealed that astrocytic Lf overexpression improved cognitive capacity by facilitating Lf secretion to neurons to inhibit β-amyloid protei...