Model‐based meta‐analysis of ethnic differences and their variabilities in clearance of oral drugs classified by clearance mechanism

• Main Authors: Hiromi Sato (Author), Rika Marutani (Author), Ryota Takaoka (Author), Daniel Mori‐Fegan (Author), Xinying Wang (Author), Kazuya Maeda (Author), Hiroyuki Kusuhara (Author), Hiroshi Suzuki (Author), Hideki Yoshioka (Author), Akihiro Hisaka (Author)
• Format: Book
• Published: Wiley, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In this study, the ethnic ratios (ERs) of oral clearance between Japanese and Western populations were subjected to model‐based meta‐analysis (MBMA) for 81 drugs evaluated in 673 clinical studies. The drugs were classified into eight groups according to the clearance mechanism, and the ER f...