Model‐based meta‐analysis of ethnic differences and their variabilities in clearance of oral drugs classified by clearance mechanism

• Những tác giả chính: Hiromi Sato (Tác giả), Rika Marutani (Tác giả), Ryota Takaoka (Tác giả), Daniel Mori‐Fegan (Tác giả), Xinying Wang (Tác giả), Kazuya Maeda (Tác giả), Hiroyuki Kusuhara (Tác giả), Hiroshi Suzuki (Tác giả), Hideki Yoshioka (Tác giả), Akihiro Hisaka (Tác giả)
• Định dạng: Sách
• Được phát hành: Wiley, 2023-08-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Abstract In this study, the ethnic ratios (ERs) of oral clearance between Japanese and Western populations were subjected to model‐based meta‐analysis (MBMA) for 81 drugs evaluated in 673 clinical studies. The drugs were classified into eight groups according to the clearance mechanism, and the ER f...