Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition

• Main Authors: Patrik Oleksak (Author), Miroslav Psotka (Author), Marketa Vancurova (Author), Olena Sapega (Author), Jana Bieblova (Author), Milan Reinis (Author), David Rysanek (Author), Romana Mikyskova (Author), Katarina Chalupova (Author), David Malinak (Author), Jana Svobodova (Author), Rudolf Andrys (Author), Helena Rehulkova (Author), Vojtech Skopek (Author), Pham Ngoc Lam (Author), Jiri Bartek (Author), Zdenek Hodny (Author), Kamil Musilek (Author)
• 格式: 图书
• 出版: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and novel compounds was evaluated using several human and...