Loss of AMP-Activated Protein Kinase Induces Mitochondrial Dysfunction and Proinflammatory Response in Unstimulated Abcd1-Knockout Mice Mixed Glial Cells

• Main Authors: Jaspreet Singh (Author), Hamid Suhail (Author), Shailendra Giri (Author)
• Format: Bog
• Udgivet: Hindawi Limited, 2015-01-01T00:00:00Z.
• Fag: article
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X-linked adrenoleukodystrophy (X-ALD) is caused by mutations and/or deletions in the ABCD1 gene. Similar mutations/deletions can give rise to variable phenotypes ranging from mild adrenomyeloneuropathy (AMN) to inflammatory fatal cerebral adrenoleukodystrophy (ALD) via unknown mechanisms. We recentl...