The effect of substance P and its common in vivo‐formed metabolites on MRGPRX2 and human mast cell activation

• Κύριοι συγγραφείς: Lin Hsin (Συγγραφέας), Nithya A. Fernandopulle (Συγγραφέας), Jie Ding (Συγγραφέας), Chris Lumb (Συγγραφέας), Nicholas Veldhuis (Συγγραφέας), John A. Karas (Συγγραφέας), Susan E. Northfield (Συγγραφέας), Graham A. Mackay (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Wiley, 2022-08-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract The tachykinin neuropeptide substance P (SP) is the canonical agonist peptide for the neurokinin 1 receptor (NK1R). More recently, it has also been shown to activate the Mas‐related G protein‐coupled receptor X2 (MRGPRX2) receptor on mast cells (MCs), triggering degranulation and release of...