The effect of substance P and its common in vivo‐formed metabolites on MRGPRX2 and human mast cell activation

• Main Authors: Lin Hsin (Author), Nithya A. Fernandopulle (Author), Jie Ding (Author), Chris Lumb (Author), Nicholas Veldhuis (Author), John A. Karas (Author), Susan E. Northfield (Author), Graham A. Mackay (Author)
• Format: Book
• Published: Wiley, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The tachykinin neuropeptide substance P (SP) is the canonical agonist peptide for the neurokinin 1 receptor (NK1R). More recently, it has also been shown to activate the Mas‐related G protein‐coupled receptor X2 (MRGPRX2) receptor on mast cells (MCs), triggering degranulation and release of...