Silencing of NAC1 Expression Induces Cancer Cells Oxidative Stress in Hypoxia and Potentiates the Therapeutic Activity of Elesclomol

• Main Authors: Yi-Jie Ren (Author), Xiao-Hui Wang (Author), Cheng Ji (Author), Yi-Di Guan (Author), Xian-Jiu Lu (Author), Xian-Rong Liu (Author), Hong-Han Zhang (Author), Ling-Chuan Guo (Author), Qiong-Hua Xu (Author), Wei-Dong Zhu (Author), Zhi-Jun Ming (Author), Jin-Ming Yang (Author), Yan Cheng (Author), Yi Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In order to survive under conditions of low oxygen, cancer cells can undergo a metabolic switch to glycolysis and suppress mitochondrial respiration in order to reduce oxygen consumption and prevent excessive amounts of reactive oxygen species (ROS) production. Nucleus accumbens-1 (NAC1), a nuclear...