Ketogal Safety Profile in Human Primary Colonic Epithelial Cells and in Mice

• Main Authors: Federica Sodano (Author), Bice Avallone (Author), Monica Tizzano (Author), Chiara Fogliano (Author), Barbara Rolando (Author), Elena Gazzano (Author), Chiara Riganti (Author), Salvatore Magliocca (Author), Mariarosaria Cuozzo (Author), Stefania Albrizio (Author), Antonio Calignano (Author), Claudia Cristiano (Author), Roberto Russo (Author), Maria Grazia Rimoli (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In our previous studies, a ketorolac-galactose conjugate (ketogal) showed prolonged anti-inflammatory and analgesic activity, causing less gastric ulcerogenic effect and renal toxicity than its parent drug ketorolac. In order to demonstrate the safer profile of ketogal compared to ketorolac, histopa...