The endogenous preproglucagon system is not essential for gut growth homeostasis in mice

• Main Authors: Pernille Wismann (Author), Pernille Barkholt (Author), Thomas Secher (Author), Niels Vrang (Author), Henrik B. Hansen (Author), Palle Bekker Jeppesen (Author), Laurie L. Baggio (Author), Jacqueline A. Koehler (Author), Daniel J. Drucker (Author), Darleen A. Sandoval (Author), Jacob Jelsing (Author)
• Format: Book
• Published: Elsevier, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The prevalence of obesity and related co-morbidities is reaching pandemic proportions. Today, the most effective obesity treatments are glucagon-like peptide 1 (GLP-1) analogs and bariatric surgery. Interestingly, both intervention paradigms have been associated with adaptive growth respo...