Evaluation of 124I-JS001 for hPD1 immuno-PET imaging using sarcoma cell homografts in humanized mice

• Main Authors: Haifeng Huang (Author), Hua Zhu (Author), Quan Xie (Author), Xiaobin Tian (Author), Xianteng Yang (Author), Fan Feng (Author), Qiyu Jiang (Author), Xinan Sheng (Author), Zhi Yang (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

JS001 (toripalimab) is a humanized IgG monoclonal antibody which strongly inhibits programmed cell death protein 1 (PD1). In this study, we used a different iodine isotype (nat/124/125I) to label JS001 probes to target the human PD1 (hPD1) antigen. In vitro, the half maximal effective concentration...