Design, Synthesis and In Vitro Investigation of Cabozantinib-Based PROTACs to Target c-Met Kinase

Design, Synthesis and In Vitro Investigation of Cabozantinib-Based PROTACs to Target c-Met Kinase

(1) Background: This investigation aimed at developing a series of c-Met-targeting cabozantinib-based PROTACs. (2) Methods: Purification of intermediate and target compounds was performed using column chromatography, in vitro antiproliferation activity was measured using a standard MTT assay and a c...

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Main Authors: Anastasia A. Sachkova (Author), Daria V. Andreeva (Author), Alexander S. Tikhomirov (Author), Alexander M. Scherbakov (Author), Diana I. Salnikova (Author), Danila V. Sorokin (Author), Fedor B. Bogdanov (Author), Yulia D. Rysina (Author), Andrey E. Shchekotikhin (Author), Ekaterina S. Shchegravina (Author), Alexey Yu. Fedorov (Author)
Format: Book
Published: MDPI AG, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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