Utilization of Polymeric Micelles as a Lucrative Platform for Efficient Brain Deposition of Olanzapine as an Antischizophrenic Drug via Intranasal Delivery

• Main Authors: Hadel A. Abo El-Enin (Author), Marwa F. Ahmed (Author), Ibrahim A. Naguib (Author), Shaymaa W. El-Far (Author), Mohammed M. Ghoneim (Author), Izzeddin Alsalahat (Author), Hend Mohamed Abdel-Bar (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schizophrenia is a mental disorder characterized by alterations in cognition, behavior and emotions. Oral olanzapine (OZ) administration is extensively metabolized (~up to 40% of the administrated dose). In addition, OZ is a P-glycoproteins substrate that impairs the blood-brain barrier (BBB) permea...