Evaluation of the potential for pharmacokinetic interaction between tirabrutinib and levonorgestrel/ethinyl estradiol in healthy female volunteers

• Hlavní autoři: Ganesh Cherala (Autor), Cara Nelson (Autor), Ying Guo (Autor), Anubhav Mathur (Autor), Thomas Tarnowski (Autor), Ahmed A. Othman (Autor)
• Médium: Kniha
• Vydáno: Wiley, 2022-06-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Abstract Tirabrutinib (TIRA), a potent and nonreversible oral Bruton tyrosine kinase inhibitor, is evaluated for treatment of certain hematological malignancies and inflammatory diseases. A drug-drug interaction study to evaluate the effect of TIRA on the pharmacokinetics of the oral contraceptive l...