Validation of genotype imputation in Southeast Asian populations and the effect of single nucleotide polymorphism annotation on imputation outcome

• Auteurs principaux: Worachart Lert-itthiporn (Auteur), Bhoom Suktitipat (Auteur), Harald Grove (Auteur), Anavaj Sakuntabhai (Auteur), Prida Malasit (Auteur), Nattaya Tangthawornchaikul (Auteur), Fumihiko Matsuda (Auteur), Prapat Suriyaphol (Auteur)
• Format: Livre
• Publié: BMC, 2018-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Background Imputation involves the inference of untyped single nucleotide polymorphisms (SNPs) in genome-wide association studies. The haplotypic reference of choice for imputation in Southeast Asian populations is unclear. Moreover, the influence of SNP annotation on imputation results has...