Trypanosoma cruzi Experimental Infection Impacts on the Thymic Regulatory T Cell Compartment.

• Main Authors: Florencia Belén González (Author), Flavia Calmon-Hamaty (Author), Synara Nô Seara Cordeiro (Author), Rodrigo Fernández Bussy (Author), Silvana Virginia Spinelli (Author), Luciano D'Attilio (Author), Oscar Bottasso (Author), Wilson Savino (Author), Vinícius Cotta- (Author), Silvina Raquel Villar (Author), Ana Rosa Pérez (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The dynamics of regulatory T cells in the course of Trypanosoma cruzi infection is still debated. We previously demonstrated that acute murine T. cruzi infection results in an impaired peripheral CD4+Foxp3+ T cell differentiation due to the acquisition of an abnormal Th1-like phenotype and altered f...