Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes

• Main Authors: Daniel S. de Jesus (Author), Tracy C.S. Mak (Author), Yi-Fang Wang (Author), Yorrick von Ohlen (Author), Ying Bai (Author), Eva Kane (Author), Pauline Chabosseau (Author), Catherine M. Chahrour (Author), Walter Distaso (Author), Victoria Salem (Author), Alejandra Tomas (Author), Markus Stoffel (Author), Guy A. Rutter (Author), Mathieu Latreille (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: β-cell dedifferentiation has been revealed as a pathological mechanism underlying pancreatic dysfunction in diabetes. We previously showed that increased miR-7 levels trigger β-cell dedifferentiation and diabetes. We used β-cell-specific miR-7 overexpressing mice (Tg7) to test the hypothe...