Synthesis and evaluation of a novel PET ligand, a GSK'963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain

• Main Authors: Hiroshi Ikenuma (Author), Aya Ogata (Author), Hiroko Koyama (Author), Bin Ji (Author), Hideki Ishii (Author), Takashi Yamada (Author), Junichiro Abe (Author), Chie Seki (Author), Yuji Nagai (Author), Masanori Ichise (Author), Takafumi Minamimoto (Author), Makoto Higuchi (Author), Ming-Rong Zhang (Author), Takashi Kato (Author), Kengo Ito (Author), Masaaki Suzuki (Author), Yasuyuki Kimura (Author)
• Format: Book
• Published: SpringerOpen, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Receptor interacting protein kinase 1 (RIPK1) is a serine/threonine kinase, which regulates programmed cell death and inflammation. Recently, the involvement of RIPK1 in the pathophysiology of Alzheimer's disease (AD) has been reported; RIPK1 is involved in microglia's...