Sequential loss of LC noradrenergic and dopaminergic neurons results in a correlation of dopaminergic neuronal number to striatal dopamine concentration

• Main Authors: Patricia eSzot (Author), Allyn eFranklin (Author), Carl eSikkema (Author), Charles W Wilkinson (Author), Murray A Raskind (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Noradrenergic neurons in the locus coeruleus (LC) are significantly reduced in Parkinson's disease (PD) and the LC exhibits neuropathological changes early in the disease process. It has been suggested that a loss of LC neurons can enhance the susceptibility of dopaminergic neurons to damage. T...