Advax4 delta inulin combination adjuvant together with ECMX, a fusion construct of four protective mTB antigens, induces a potent Th1 immune response and protects mice against Mycobacterium tuberculosis infection

• Main Authors: Bruno de Paula Oliveira Santos (Author), Monalisa Martins Trentini (Author), Renato Beilner Machado (Author), Mara Rúbia Nunes Celes (Author), André Kipnis (Author), Nikolai Petrovsky (Author), Ana Paula Junqueira-Kipnis (Author)
• פורמט: ספר
• יצא לאור: Taylor & Francis Group, 2017-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Tuberculosis (TB) remains a main public health concern and 10.4 million new cases occurred in 2015 around the world. BCG is the only approved vaccine against TB, but has variable efficacy and new vaccines are needed. We developed two new mTB vaccine candidates based on the recombinant fusion protein...