The Prenylflavonoid Xanthohumol Reduces Alzheimer-Like Changes and Modulates Multiple Pathogenic Molecular Pathways in the Neuro2a/APPswe Cell Model of AD

• Main Authors: Xianfeng Huang (Author), Jing Wang (Author), Xiao Chen (Author), Pan Liu (Author), Shujin Wang (Author), Fangchen Song (Author), Zaijun Zhang (Author), Feiqi Zhu (Author), Xinfeng Huang (Author), Jianjun Liu (Author), Guoqiang Song (Author), Peter S. Spencer (Author), Xifei Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has proved refractory to drug treatment. Given evidence of neuroprotection in animal models of ischemic stroke, we assessed the prenylflavonoid xanthohumol from the Common Hop (Humulus lupulus L.) for therapeutic potentia...