Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

• Main Authors: Chenchen Han (Author), Yifan Li (Author), Yuwen Zhang (Author), Yang Wang (Author), Dongqian Cui (Author), Tingting Luo (Author), Yu Zhang (Author), Qian Liu (Author), Hao Li (Author), Chun Wang (Author), Dexiang Xu (Author), Yang Ma (Author), Wei Wei (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression of G protein coupled receptor kinase 2 (GRK2) of FLS plays a critical role in RA progression, the increase of...