Leveraging in vitro and pharmacokinetic models to support bench to bedside investigation of XTMAB-16 as a novel pulmonary sarcoidosis treatment

• Main Authors: Elliot Offman (Author), Noopur Singh (Author), Mark W. Julian (Author), Landon W. Locke (Author), Sabahattin Bicer (Author), Jonah Mitchell (Author), Thomas Matthews (Author), Kirsten Anderson (Author), Elliott D. Crouser (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Sarcoidosis is a chronic, multisystem inflammatory disorder characterized by non-caseating epithelioid granulomas; infiltration of mononuclear cells; and destruction of microarchitecture in the skin, eye, heart, and central nervous system, and the lung in >90% of cases. XTMAB-16 is a...