Oxidative Stress and Cellular Senescence Are Involved in the Aging Kidney

• Main Authors: Laura Marquez-Exposito (Author), Lucia Tejedor-Santamaria (Author), Floris A. Valentijn (Author), Antonio Tejera-Muñoz (Author), Sandra Rayego-Mateos (Author), Vanessa Marchant (Author), Raul R. Rodrigues-Diez (Author), Irene Rubio-Soto (Author), Sebastiaan N. Knoppert (Author), Alberto Ortiz (Author), Adrian M. Ramos (Author), Roel Goldschmeding (Author), Marta Ruiz-Ortega (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic kidney disease (CKD) can be considered as a clinical model for premature aging. However, non-invasive biomarkers to detect early kidney damage and the onset of a senescent phenotype are lacking. Most of the preclinical senescence studies in aging have been done in very old mice. Furthermore,...